Skin rashes may occur during therapy with lamotrigine, severe skin reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis have been reported, especially in children, and usually occur within 8 weeks of starting lamotrigine. Symptoms such as fever, malaise, flu-like symptoms, drowsiness, lymphadenopathy, facial edema and, rarely hepatic dysfunction, leucopenia, and thrombocytopenia have also been reported in conjunction with rashes as part of a hypersensitivity syndrome.
Other adverse effects include angioedema and photosensitivity, diplopia, blurred vision, and conjunctivitis, and dizziness, drowsiness, insomnia, headache, ataxia, nystagmus, tremor, tiredness, nausea and vomiting, irritability and aggression, hallucinations, agitation and confusion.